Cancer cells produce small amounts of their own form of
collagen, creating a unique extracellular matrix that affects the tumor
microbiome and protects against immune responses, according to a new study by
researchers. This abnormal collagen structure is fundamentally different from
normal collagen made in the human body, providing a highly specific target for
This study, published in Cancer Cell, builds upon
previously published findings from the chair of Cancer Biology to
bring a new understanding of the unique roles of collagen made by fibroblasts
and by cancer cells.
cells make a unique form of collagen, protecting them from immune response”;
2. Trauma of diagnosis stays with eye disease patients
A research team interviewed patients of a range of ages
who had been diagnosed with eye disease in England over the course of several
decades and assessed the psychological impact of the way their diagnosis was
communicated. The study is published in BMJ Journal.
Interviewees had been diagnosed with a variety of
conditions, including diabetic retinopathy, macular degeneration, Stargardt
disease, and retinitis pigmentosa, all of which can cause significant vision
The interviews showed four themes; the convoluted process of
being diagnosed; the impact of clinicians’ words; the search for information;
and reflections on what could be improved.
Reference: “Trauma of diagnosis stays with eye disease
patients”; ANGLIA RUSKIN UNIVERSITY, BMJ Open. DOI:10.1136/bmjopen-2021-059970.
3.Women are urged to eat potassium-rich foods to improve their heart health
Women who eat bananas, avocados, and salmon could reduce the
negative effects of salt in their diet, according to a study published today
in the European Heart Journal, a journal of the European Society of
Cardiology (ESC). The study found that potassium-rich diets were
associated with lower blood pressure, particularly in women with high salt intake.
The study included 24,963 participants (11,267 men and
13,696 women) of the EPIC-Norfolk study, which recruited 40 to 79-year-olds
from general practices in Norfolk, UK, between 1993 and 1997. The average age
was 59 years for men and 58 years for women. Participants completed a
questionnaire on lifestyle habits, blood pressure was measured, and a urine
sample was collected. Urinary sodium and potassium were used to estimate
dietary intake. Participants were divided into tertiles according to sodium intake
(low/medium/high) and potassium intake (low/medium/high).
Reference: “Women urged to eat potassium-rich foods to
improve their heart health”; EUROPEAN SOCIETY OF CARDIOLOGY, European Heart
Journal. DOI- 10.1093/eurheartj/ehac313.
4. Potential target for Type 1 diabetes treatment
A world-first study by Monash University, in
Melbourne, Australia have discovered a pathway to the regeneration of insulin in
pancreatic stem cells, a major breakthrough toward new therapies to treat Type
1 and Type 2 diabetes.
Using the pancreas stem cells of type 1 diabetic donors,
researchers were able to effectively reactivate them to become
insulin-expressing and functionally resemble beta-like cells through the use of
a drug approved by the US Food and Drug Administration but not currently
licensed for diabetes treatment.
Reference: Nature journal, Signal Transduction and
Targeted Therapy titled: Inhibition of pancreatic EZH2 restores
progenitor insulin in T1D donor; DOI: 10.1038/s41392-022-01034-7.