Clinical Trials & Research

Mount Sinai researchers have developed a therapeutic agent that shows high effectiveness in vitro at disrupting a biological pathway that helps cancer survive, according to a paper published in Cancer Discovery, a journal of the American Association for Cancer Research, in July. The therapy is an engineered molecule, named MS21, that causes the degradation of
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A form of gene therapy protects optic nerve cells and preserves vision in mouse models of glaucoma, according to research supported by NIH’s National Eye Institute. The findings suggest a way forward for developing neuroprotective therapies for glaucoma, a leading cause of visual impairment and blindness. The report was published in Cell. Glaucoma results from
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In the evolving field of cancer biology and treatment, innovations in organ-on-a-chip microdevices allow researchers to discover more about the disease outside the human body. These organs-on-chips serve as a model of the state an actual cancer patient is in, thus allowing an opportunity to finding the correct treatment before administering it to the patient.
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University of Virginia School of Medicine researchers have discovered a previously unknown repair process in the brain that they hope could be harnessed and enhanced to treat seizure-related brain injuries. Common seizure-preventing drugs do not work for approximately a third of epilepsy patients, so new and better treatments for such brain injuries are much needed.
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A research team led by Dr Rosario Delgado from the UAB Department of Mathematics, in collaboration with the Hospital de Mataró, developed a new machine learning-based model that predicts the risk of mortality of intensive care unit patients according to their characteristics. The research was published in the latest edition of the journal Artificial Intelligence
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Scientists around the world are working to understand the various aspects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), from its infection mechanisms to its molecular engagements. In-depth knowledge of the virological dynamics of SARS-CoV-2 will be crucial in developing effective vaccines and therapeutics to combat the ongoing coronavirus disease (COVID-19) pandemic in the long
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The rapid development and rollout of effective vaccines to the global population are key measures to help arrest the ongoing coronavirus disease 2019 (COVID-19) pandemic. The current pandemic has been caused by a highly transmissible respiratory virus, namely, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At present, several vaccines have received emergency use authorization (EUA)
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Clinical trials are vital and ongoing, particularly during the current pandemic. However, the risk from variants remains a concern. A number of clinical pathologists from Cerba Laboratory recently presented some approaches on how to manage SARS CoV 2 variants during the clinical trial process. Dr. Benedicte Roquebert is based in the microbiology department of Cerba
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A nationwide case-control study conducted in France has assessed the efficacy of mRNA-based coronavirus disease 2019 (COVID-19) vaccines against original severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants, including B.1.1.7, B.1.351, and P1. In real-life pandemic situations, the two-dose regimen of mRNA vaccines has shown equivalent protective efficacy against the original virus and
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A recent study conducted at the University of Texas Science Center, Houston, in the USA, has revealed that upon infection, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) alters the host chromatin architecture to suppress antiviral interferon-responsive genes and augment inflammatory genes. The study is currently available on the bioRxiv* preprint server. Background SARS-CoV-2, the causative
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The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has baffled researchers with its propensity to cause symptoms of largely unpredictable severity in the affected individuals. While most patients have mild or no symptoms, a significant minority develop severe or critical symptoms, and some have a fatal
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During the height of the pandemic, some hospitals were overwhelmed with patients seeking treatment for COVID-19. This situation could happen again during future outbreaks, especially with SARS-CoV-2 variants of concern on the rise. Now, researchers reporting in ACS’ Analytical Chemistry have developed a blood test to predict which people infected with COVID-19 are most likely
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You can’t make a banana split without bananas. And you can’t generate stable regulatory T cells without Vitamin C or enzymes called TET proteins, it appears. Regulatory T cells (Tregs) help control inflammation and autoimmunity in the body. Tregs are so important, in fact, that scientists are working to generate stable induced Tregs (iTregs) in
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A study in Norway has recently highlighted a significant association between gut microbiota alteration and persistent respiratory dysfunction in coronavirus disease 2019 (COVID-19) patients. The study reveals that altered diversity and composition of the gut microbiota together with increased plasma levels of lipopolysaccharide-binding protein (LBP) is associated with respiratory dysfunction in COVID-19 patients even after
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Three-dimensional organoid structures grown in the lab allow deeper, almost in situ investigation of a biological system, without the use of living animals. In a paper recently uploaded to the preprint server bioRxiv*, organoids generated from human specimens are utilized to investigate the way in which SARS-CoV-2 interacts with the numerous cells of the intestinal
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The plasticity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome has resulted in the development of several variants of concern (VOCs), largely due to mutations to the spike protein that enhance affinity towards the ACE2 receptor. Constant monitoring for the development of these and other mutations that enhance transmissibility of SARS-CoV-2 or contribute
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Following acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), many patients have reported long-standing symptomatology even after a reasonable period of convalescence. This has been dubbed long COVID and has been noted to occur in as many as 80% of patients at up to four months from the onset of acute symptoms. A
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The ongoing coronavirus disease pandemic 2019 (COVID-19), which is caused by a novel betacoronavirus – namely the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) –  has led to immense disruptions to public health and economic wellbeing worldwide. Scientists have developed COVID-19 vaccines at a record speed, and several of these have received emergency use approval
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The rapid development and rolling out of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been considered as a huge step forward towards containing the ongoing coronavirus disease 2019 (COVID-19) pandemic. However, the continual emergence of SARS-CoV-2 variants across the world has made the scientific community skeptical towards the effectiveness of the available
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An interesting new study, released as a preprint on the medRxiv* server, reports that vaccine hesitancy in the UK is driven not, as is commonly thought, by the so-called ‘infodemic’ of misinformation that has characterized much public messaging during the coronavirus disease 2019 (COVID-19) pandemic. Instead, the personality of the individual, the ability to trust
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In the largest study of its kind, an investigation by UC San Francisco has found no evidence that moderate coffee consumption can cause cardiac arrhythmia. In fact, each additional daily cup of coffee consumed among several hundred thousand individuals was associated with a 3 percent lower risk of any arrhythmia occurring, including atrial fibrillation, premature
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CAMBRIDGE, Mass., July 19, 2021 /PRNewswire/ – Anthos Therapeutics, a clinical-stage biopharma company developing innovative therapies for cardiovascular and metabolic diseases, today announced final results from the Phase 2 ANT-005 study with its novel investigational anticoagulant abelacimab. Published today in the New England Journal of Medicine,1 and simultaneously presented as a late breaker at the International Society of Thrombosis and
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Why do alterations of certain genes cause cancer only in specific organs of the human body? Scientists at the German Cancer Consortium (DKTK), the Technical University of Munich (TUM), and the University Medical Center Göttingen have now demonstrated that cells originating from different organs are differentially susceptible to activating mutations in cancer drivers: The same
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The research team led by Prof. WEI Haiming and Prof. TIAN Zhigang from Division of Life Sciences and Medicine, University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS), collaborating with the research group led by Prof. SUN Zimin from the First Affiliated Hospital of USTC revealed the pathological mechanism
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Russian scientists have synthesized chemical compounds that can stop the degeneration of neurons in Alzheimer’s, Parkinson’s, and other severe brain pathologies. These substances can provide a breakthrough in the treatment of neurodegenerative pathologies. New molecules of pyrrolyl- and indolylazine classes activate intracellular mechanisms to combat one of the main causes of “aged” brain diseases –
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